Furthermore, the high expression of αKlotho protein in the kidneys has shown a positive effect in the treatment of CI-AKI, as it can protect the kidneys and HK-2 cells from contrast agent-induced damage by inhibiting the activation of the NLRP3 inflammasome and promoting autophagy (Zhu et al., 2021). The gene discussed is NLRP3; the disease is acute kidney injury.