Regarding the appearance of tau in dendrites of AD neurons, we have recently reported that tau mRNA and mRNAs for GSK3β and CDK5, known to be major tau kinases, are distributed in dendrites and that hyperphosphorylated tau with AD epitopes is locally synthesized in response to NMDA receptor-mediated stimulation [[5], [6], [7]]. This evidence concerns the gene CDK5 and Alzheimer disease.