ECG: electrocardiogram, CV: cardiovascular, EF: ejection fraction, HF: heart failure, TTE: transthoracic echocardiogram, LV: left ventricle, CK-MB: creatine kinase-MB, BNP: B-type natriuretic peptide, PVC: premature ventricular contraction, TAPSE: tricuspid annular plane systolic excursion, ED: emergency department. The gene discussed is NPPB; the disease is heart failure.