In a study of metastatic melanoma, PD-L1+/CD8+TILs (PD-L1 expression on tumor cells (TC) ≥ 5%) status was identified as a significant independent prognostic factor for improved OS (HR = 0.138, 95% CI 0.024-0.779, p = 0.022) (15). This evidence concerns the gene CD8A and neoplasm.