By TRIO-WES analysis, despite the small cohort of patients, we got seven de novo variants, one in a possible novel candidate gene (DROSHA), and four in genes not apparently correlated with SCAD or CTDs (SHANK2, SUPV3L1, SBNO1, and MCHR2) (Supplementary Table S3). This evidence concerns the gene MCHR2 and spontaneous coronary artery dissection.