By TRIO-WES analysis, despite the small cohort of patients, we got seven de novo variants, one in a possible novel candidate gene (DROSHA), and four in genes not apparently correlated with SCAD or CTDs (SHANK2, SUPV3L1, SBNO1, and MCHR2) (Supplementary Table S3). The gene discussed is SBNO1; the disease is spontaneous coronary artery dissection.