By TRIO-WES analysis, despite the small cohort of patients, we got seven de novo variants, one in a possible novel candidate gene (DROSHA), and four in genes not apparently correlated with SCAD or CTDs (SHANK2, SUPV3L1, SBNO1, and MCHR2) (Supplementary Table S3). Here, SHANK2 is linked to spontaneous coronary artery dissection.