Platelets facilitate the survival and proliferation of tumor cells through the secretion of various cytokines, including vascular endothelial growth factor (VEGF), transforming growth factor-β (TGF-β), and platelet-derived growth factor (PDGF) (45).Furthermore, chemokines associated with platelets have the capacity to modulate immune responses within the tumor microenvironment and influence tumor angiogenesis (46). This evidence concerns the gene TGFB1 and neoplasm.