Previous evidence shows that CXCL12 mediates plasma cell-like DC transport to tumor and Treg cells homing to bone marrow microenvironment (67); In addition, it stimulates antigen-specific T lymphocytes and macrophages to express pro-angiogenic factors by mediating the polarization of T cells to Treg (68, 69) and producing DC with poor function (70). Here, CXCL12 is linked to neoplasm.