STC1 and neoplasm: So far, multiple experimental studies have demonstrated that STC1 affected cancer cell proliferation (15), migration (16), metastasis (17), apoptosis (18), stem cell properties (19), epithelial-mesenchymal transition (EMT) (20), etc. Moreover, a number of clinical studies have validated that STC1 is aberrantly expressed in diverse tumor tissues and associated with patients prognosis (13, 21, 22).