CD274 and neoplasm: Similarly, in colorectal cancer, TAMs secreted the immunosuppressive factor TGF-Β, promoted the expression of hypoxia-inducible factor 1α (HIF-1α) and then increased tribbles pseudokinase 3 (TR1B3), activated the Β-catenin/Wnt signaling pathway, enhanced the expression of PD-L1 on the cell membrane surface, and played a role in cell invasion and tumor immunity (10).