In addition, STC1 is involved in many cancer-related signaling pathways, such as notch1-sex determining region Y-box 2 (Notch1-SOX2) (23), extracellular signal-regulated kinases1/2 (ERK1/2) (24), nuclear factor-kappaB (NF-ΚB) (17) and jun-N-terminal kinase (JNK) (25) signaling pathways, etc. In brief, STC1 is associated with multiple physiological and pathophysiological processes of tumorigenesis and progression. This evidence concerns the gene NOTCH1 and cancer.