NBR1 and neoplasm: It was found that the exosome LINC01232 antigen from M2-type TAMs promoted the transcription of NBR1 by binding to E2F2, and NBR1 binds to MHC-I protein, mediating the increased degradation of MHC-I in the autophagolysosome, eventually decreased the expression of MHC-I on the surface of tumor cells.