(61) found that CC motif chemokine ligand 5 (CCL5) secreted by TAMs induced upregulation of PD-L1 protein in colon cancer cells through p65/signal transducer and activator of transcription 3/COP9 signalosome 5 (p65/STAT3-CSN5) pathway, which enabled colon cancer cells to evade immune surveillance. The gene discussed is COPS5; the disease is malignant colon neoplasm.