In TIMs, METTL3-mediated m6A modification of Jak1 mRNA enhances the translation efficiency of Jak1 protein and subsequent STAT3 protein phosphorylation process, thereby strengthening the immunosuppressive function of TIMs, which is associated with poorer prognosis and tumor progression in colorectal cancer patients (83). This evidence concerns the gene METTL3 and neoplasm.