The results of KEGG enrichment analysis on co-DEGs revealed that the co-upregulated genes were primarily enriched in the PI3K-Akt, MAPK, NF kappa B, and HIF-1 signaling pathway (Fig. 1D), while the co-downregulated genes were enriched in Huntington's disease, neurogenesis pathways, PD, Alzheimer's disease, citate cycle, and thermogenesis (Fig. 1E). Here, AKT1 is linked to juvenile Huntington disease.