Fig. 2H and I shows reasonable targeting relationships and target networks for each group. We selected miR-187-3p related to circFTO and EEF2 for further analysis, as this miR-187-3p showed consistent trends compared to other miRNAs in iPSCs (logFC = −0.346) and neurons (logFC = −0.346), which were all derived from the healthy group and PD patient biopsies. Supplementary Tables 4 and 5 show the predicted binding related parameters. Based on the predictive tools, we performed spatial structure fitting of circFTO, miR-187-3p (Fig. 2J), miR-187-3p, and EEF2 (Fig. 2K). This evidence concerns the gene EEF2 and Parkinson disease.