Kameshima et al. found that knocking down EEF2 and reducing EEF2K activity significantly inhibited low-energy environment-induced neuronal apoptosis and autophagy [22]miR-187-3p inhibitor attenuates cerebral ischemia/reperfusion injury by regulating Seipin-mediated autophagic flux, as high levels of EEF2 may represent worsening symptoms of neurodegenerative diseases. This evidence concerns the gene EEF2K and neurodegenerative disease.