As such, the circulating levels of circFTO can be used as a biomarker for the early diagnosis of PD to determine the risk level and disease severity of the population because normal or even low levels of circ-FTO content can reduce the adsorption of miR-187-3p, thereby inhibiting the potential inflammatory activation of EEF2/EEF2K. The gene discussed is EEF2K; the disease is Parkinson disease.