From an immunological perspective, AD is predominantly influenced by the Th2 pathway (IL‐4 and IL‐13), while also involving varying degrees of involvement from the Th1 (interferon [IFN]‐γ), Th22 (IL‐22), and Th17 (IL‐17 and IL‐26) immune pathways.119, 120. This evidence concerns the gene IL4 and Alzheimer disease.