KCs participate in the intracellular signal transduction cascade through pathogen recognition receptor (PRRs), such as Toll‐like receptors (TLRs) and Dectin‐1, thereby upregulating proinflammatory factors and chemokines, which subsequently leads to inflammatory cell infiltration, immune dysregulation, and ultimately promotes the pathophysiological process of AD.73, 74. The gene discussed is TBCE; the disease is Alzheimer disease.