Clinically, AD presents with acute pruritus, erythematous papules with scaling, plasma exudation, and itching, which significantly impair the epidermal barrier, leading to dysregulation of immune‐modulating proteins, including interleukins (ILs) IL‐25 and IL‐33, in skin epithelial cells.18, 23, 24, 25, 26. The gene discussed is IL33; the disease is Alzheimer disease.