IL13 and Alzheimer disease: Moreover, As outlined in our review, a hallmark of AD is profound pruritus, with the LT axis playing a crucial role in acute pruritic episodes by interacting with sensory neurons in the skin IL‐13 acts as a direct enhancer in various pruritic and neuroactive pathways and clinical studies indicate that sustained administration of IL‐13 receptor inhibitors, such as lebrikizumab and tralokinumab, provides relief from itch in patients with AD.339, 340, 341