Additionally, a single‐cell transcriptome analysis of the skin in lesion areas of AD patients found that lesional AD samples were characterized by an expansion of and tissue‐resident memory (TRM) T cells (CD69+CD103+), as well as a higher prevalence of type 2 (IL13+)/type 22 (IL22+) T cells compared with type 1 (IFNG+) cells in lesional AD skin.118. This evidence concerns the gene CD69 and Alzheimer disease.