Unfortunately, the reverse MR analysis did not show a causal relationship (OR [95% CI], 0.953 [0.859–1.057], p = 0.36); there is no causal relationship between the gut microbiome Lachnospiraceae and COPD (OR [95% CI], 1.074 [0.907–1.274], p = 0.40); and no causal relationships were found with downstream related genes CXCL8, EGFR, and IL6 in relation to COPD. This evidence concerns the gene EGFR and chronic obstructive pulmonary disease.