Baicalein dose-dependently upregulated E-cadherin, the cleaved Caspase-3 and downregulated the expression of Vimentin, Snail, MMP2, MMP9, Bcl-2, p-PI3K, p-AKT, and p-mTOR in HGC-27 and SGC-7901 cells, which appeared to inhibit tumor growth in vivo and in vitro. This evidence concerns the gene MTOR and neoplasm.