In addition, baicalein has been proved to dose-dependently potentiate the inhibitory effect of irinotecan on proliferation of HT-29 cells accompanied by the inhibitory effect of Yes-related protein (YAP), large-tumor suppressor kinase 1 (LATS1), and phosphorylation of Src, which plays an important role as a non-receptor protein complex kinase in EMT of CRC (Meng XC et al., 2022; Sadri F et al., 2023). The gene discussed is YAP1; the disease is colorectal carcinoma.