Luo et al. (2023) reported that oleanolic acid significantly suppressed keloid fibroblast proliferation and reduced ECM deposition by increasing the level of MMP-1, suggesting that oleanolic acid might be a potent drug for treatment of keloids. Similarly, Jeon et al. (2016) also found that hepatocyte growth factor can be used to treat keloids by increasing MMP-1 expression. Further study showed that rats were treated with MMP-1 by intraperitoneal injection significantly reduced scar formation (Keskin et al., 2021). This evidence concerns the gene HGF and keloid.