The bubble map of relevant signaling Pathways prepared according to the p-value showed that the anti-exercise fatigue of fresh-cut pitaya polyphenols in-volved disease signaling Pathways in cancer, endocrine resistance, Lipid and atherosclerosis, EGFR tyrosine kinaseinhibitor resistance, signal transduction pathway (PI3K/AKT signaling pathway, HIF-1 signaling pathway), etc. (Figure 2B). Here, PIK3CA is linked to atherosclerosis.