The known CRC susceptibility genes related to “DNA repair,” MLH1, MSH2, MSH3, MSH6, MUTYH, NTHL1, PMS2, POLD1 and POLE, formed the core of the network, to which the genes CHEK2, EXO1, FAAP24, FANCI, RECQL and RECQL5 from our list were connected. This evidence concerns the gene EXO1 and colorectal carcinoma.