The known CRC susceptibility genes related to “DNA repair,” MLH1, MSH2, MSH3, MSH6, MUTYH, NTHL1, PMS2, POLD1 and POLE, formed the core of the network, to which the genes CHEK2, EXO1, FAAP24, FANCI, RECQL and RECQL5 from our list were connected. The gene discussed is MSH2; the disease is colorectal carcinoma.