WDPCP and psychiatric disorder: This gene was previously identified as a risk-increasing genome-wide significant finding in a cross-disorder study of the impulsivity-compulsivity spectrum.31 WDPCP is also associated with DNA methylation in past child soldiers32 and tinnitus prevalence.33 These findings, along with the lack of enrichment for psychiatric genetic correlates and enrichment of putatively causal relationships with body structures, support the identity of female PTS-f1 as a general factor of non-psychiatric disease/disorder risk.