CD33 and neoplasm: IL-7, a pleiotropic cytokine, primarily fulfills its role in the immune system by promoting lymphocyte development and ensuring homeostasis.[59] IL-7 is thought to play a role in breast cancer pathogenesis, promoting the growth and survival of tumor cells in culture.[60] In tumor immunity, HLA-DR+ CD4+ can activate other immune cells, attack tumor cells, and promote the apoptosis of tumor cells, thereby inhibiting tumor growth.[61] HLA DR on CD33br HLA DR+ CD14‐ integrates the associated characteristics of CD33, HLA DR, and CD14 and may serve as a specialized antigen-presenting cell.