STAT3 and breast cancer: It can induce cell cycle arrest, apoptosis, and autophagy, while inhibiting cancer cell proliferation, invasion, and metastasis, thereby contributing to the prevention of breast cancer.[62,63] TCM, a widely used complementary therapy in cancer treatment, employs natural compounds and formulas to regulate gene and protein expression through pathways such as PI3K/AKT, JAK2/STAT3, MAPK, and Wnt/β-catenin.