Guizhi Fuling pills/capsules (GZFL) is a traditional Chinese medicine formulation recommended for the management of EMs, and for adjuvant treatment of endosis after surgery.[10] A randomized controlled trial (RCT) that included 353 dysmenorrhea patients showed that GZFL substantially mitigated the intensity of dysmenorrhea.[11] Additionally, studies have shown that GZFL can improve endometrial hyperplasia[12] and reduce the serum levels of PGF2α and COX-2 in dysmenorrhea rats.[13]. This evidence concerns the gene PTGS2 and Dysmenorrhea.