This complex facilitates platelet tethering and the initiation of platelet aggregation at locations of vascular damage.[68] VWF is crucial in maintaining hemostasis by facilitating platelet adherence to vascular injury sites through the creation of a molecular bridge between the platelet–surface receptor complex, GPIb, and the subendothelial collagen matrix.[69] Thus, most genes involved in the clotting process may develop coagulation disorders, leading to changes in blood flow. The gene discussed is VWF; the disease is blood coagulation disease.