Previous studies have revealed that Cu is closely involved in cell proliferation, tumor metastasis, angiogenesis and the remodeling of tumor microenvironments via various molecular mechanisms.[10,11] Moreover, Cu can regulate the expression of PD-L1 in tumor cells, thus affecting anti-PD-L1 antitumor therapy.[12] The above studies all illustrate the importance of Cu in tumor cells. This evidence concerns the gene CD274 and neoplasm.