SACK1A and neoplasm: FAM83A, a family member A gene with sequence similarity 83, was identified as a tumor-promoting gene that is upregulated in several malignancies and was significantly associated with poor prognosis in tumors.[22–26] In addition, overexpression of FAM83A may affect PD-L1 expression and resistance to EGFR-TKI drugs, which may affect the efficacy of immunotherapy and targeted therapy.[27,28] It was evident that the 2 genes included in the risk model were closely related to the progression and prognosis of tumors.