The transcription factor Nrf2, which regulates antioxidant responses, is notably implicated in reducing susceptibility to ferroptosis.[57] High-fat diets decrease Nrf2 expression via the AKT/mTOR/ATG7 pathway, with significant reductions observed in ATG gene knockout mice, leading to enhanced ferroptosis.[58] However, upregulation of Nrf2 expression not only inhibits ferroptosis but also improves outcomes in NAFLD. The gene discussed is AKT1; the disease is metabolic dysfunction-associated steatotic liver disease.