Keywords in the green cluster include melatonin, metformin, quercetin, lipid metabolism, etc. Keywords in the red cluster include cholesterol, triglycerides, autophagy, hydrogen sulfide, fatty liver, etc. Keywords in the blue cluster include cellular autophagy, inflammation, hepatocellular carcinoma, metabolic syndrome, high-fat diet, hepatic steatosis, NRF2, mTOR, etc. Keywords in the purple cluster include aging, network pharmacology, etc. Keywords in the yellow cluster include endoplasmic reticulum stress, protein response, liver injury, cell engulfment, oxidative stress, etc. The gene discussed is MTOR; the disease is fatty liver disease.