It also involves the stimulation of the mitogen-activated protein kinase pathway, decreased uptake of cysteine, and depletion of glutathione.[48,49] Recent studies have indicated that approximately one-third of NAFLD patients exhibit elevated liver iron levels, rendering the liver highly susceptible to oxidative damage.[50] This excessive accumulation of iron and resultant oxidative stress are pivotal factors initiating liver injury and disease progression in NAFLD,[51] thereby establishing a close association between ferroptosis and NAFLD. Here, WNK2 is linked to metabolic dysfunction-associated steatotic liver disease.