SOCS1 and neoplasm: Pair-wise comparisons between normal and tumor samples within the TCGA database revealed SOCS1 to be highly expressed in BRCA, ESCA, HNSC, LIHC, LUAD, LUSC, READ, STAD, and THCA, and it exhibits low expression in BLCA, CESC, COAD, KIRC, PRAD, and UCEC (Fig. 1A and B).