STAT3 and central nervous system cancer: GSEA enrichment analysis pinpointed the signaling pathways implicating SOCS1 in glioma patients, indicating that high SOCS1 expression in the CGGA glioma samples correlates with allograft rejection, programmed cell death, IL-6 and JAK-STAT3 signaling pathways, and interferon-gamma responses (Fig. 3E).