Compared with men, women may be more vulnerable to sleep disorders, with greater increases in CRP and IL-6,[65,66] greater increases in inflammatory cytokines produced by TLR-4-stimulated monocytes, and greater increases in NF-κB.[67,68] Liu et al[69] found that poor sleep quality is associated with elevated plasma hs-CRP levels in women but not in men among the adult population in the United States. Here, TLR4 is linked to sleep disorder.