NLRP3 and early-onset autosomal dominant Alzheimer disease: Dysregulation of the NLR-family pyrin domain containing 3 (NLRP3) inflammasome has emerged as a key contributor to the pathogenesis of numerous human diseases including atherosclerosis (Duewell et al, 2010), gout (Martinon et al, 2006), multiple sclerosis (Inoue et al, 2012), Alzheimer’s disease (Halle et al, 2008), and several cancers (Kolb et al, 2014; Karki et al, 2017; Sekaran et al, 2024).