For planned PA after a meal (up to 2 h after a meal), a higher glucose target should be set first, where possible, followed by performing a prandial bolus insulin reduction (e.g. around 25–33% reduction) to help reduce prandial insulin on board (IOB) and the risk of hypoglycaemia (see ESM 1 for more details on IOB). This evidence concerns the gene INS and Hypoglycemia.