The increased phospho-EGFR+ epithelial area and Ki-67+ basal cells observed in WT and Rag1KO mice were significantly diminished in DKO mice lacking ILCs (Fig. 6H, I and Supplementary Fig. 7F), supporting the critical role of the ILC2-Areg-EGFR pathway in EoE pathogenesis. This evidence concerns the gene EGFR and eosinophilic esophagitis.