When comparing mice treated with the TGFβ vaccine to those receiving the vaccine alongside an anti-IL-6R antibody, we found that inhibition of IL-6 signaling reduced overall T-cell infiltration within the tumor (Fig. 3F), including decreases in CD4+ T cells (Fig. 3G), CD8+ T cells (Fig. 3H) and regulatory T cells (Fig. 3I). This evidence concerns the gene CD8A and neoplasm.