MMP2 and Hyperglycemia: In further support for the hyperglycemic effect on MMP2 activity, hyperglycemia reduced HCASMC migration (8 h 34.89 SD 6.4 vs 44.34 SD 9.3% wound closure p = 0.06; 12 h 45.96 SD 2.2 vs 57.14 SD 9.2% wound closure p = 0.01; 16 h 63.7 SD 5.991 vs 72.02 SD 4.4% wound closure p = 0.01, respectively; Supplementary Fig. 16).