PPARGC1A and Hyperglycemia: Conversely, liver‐specific Gadd45β gene knockout mice exhibit hyperglycaemia resistance induced by high‐fat diet or steroids [17], which is attributed to the joint promotion of DNA demethylation of PGC‐1α promoter by Gadd45β and TET1, with stimulating PGC‐1α expression and promoting tumour development or hyperglycaemia.