Conversely, liver‐specific Gadd45β gene knockout mice exhibit hyperglycaemia resistance induced by high‐fat diet or steroids [17], which is attributed to the joint promotion of DNA demethylation of PGC‐1α promoter by Gadd45β and TET1, with stimulating PGC‐1α expression and promoting tumour development or hyperglycaemia. Here, PPARGC1A is linked to neoplasm.