Although the liver cancer inducers diethylnitrosamine (DEN) and ethylnitrosourea (ENU) significantly and dose‐dependently increase Gadd45β expression 4 h after treatment of mouse liver [27], this should be related to the early stress response caused by hepatocellular injury and does not affect the expression of advanced tumours after injury. The gene discussed is GADD45B; the disease is liver cancer.