CBD:↓ spheres formation in treated NSCLC‐CR vs. control or cisplatin‐treated cells.↓ CD44+ and CD133+ cell population in treated spheres (41.73% in H460‐CR, and 81.70% in A549‐CR;) vs. controls (91% in H460, and 95.877% in A549)↓ protein expression of Snail, Nanog, and Vimentin in both NSCLC‐CR. Here, CD44 is linked to non-small cell lung carcinoma.