However disturbances in BCAA enzymes expression and accumulation of BCAA were shown in unilateral ureteral obstruction (UUO) mice (8), so further studies will be needed to define the effects of BT2 in other fibrotic injury models, as well as DKD, and other kidney diseases with hyperactivation of mTORC1, such as autosomal dominant polycystic kidney disease (ADPKD) (44). Here, ARID4B is linked to diabetic kidney disease.