ABCA4 and retinal degeneration: Abca4−/−Rdh8−/− mice in response to light display an acceleration in retinal degeneration and elevation of atRAL levels in the retina compared to light-free Abca4−/−Rdh8−/− mice (10, 12, 13), thereby enabling them to be an ideal acute model for investigating the pathogenesis of STGD1 and dAMD, and their therapy with drugs.