It is not established whether reduced NO bioavailability is a universal feature of MetS and/or T2DM, however nitrite improved glycemia in db/db mice (one month treatment) (29) and oblep mice (one week treatment) (30), whilst nitrate improved insulin sensitivity in high-fructose-fed rats over 10 weeks (31), high-fat diet low-dose streptozotocin T2DM rats over two months (32) and high-fat-high-fructose-fed mice over one month (33). Here, INS is linked to type 2 diabetes mellitus.