Intranasal administration to mice with recombinant IFN-α and IFN-β (IFN-α/β) at the time of infection completely protected mice from the ancestral or Delta P80 virus infection, highlighting the importance of type I IFNs in defense against SARS-CoV-2 infection (Fig 6A–6C). The gene discussed is IFNB1; the disease is viral infectious disease.