The mechanisms underlying this exacerbation of inflammation and CRC by fish oil may involve alterations in CD8+ T-cell populations and FOXP3 expression [111], increased macrophage secretion of pro-inflammatory TNF-α, reduced anti-inflammatory IL-10 secretion [114], and reduced adiponectin expression in colon tissues [113]. The gene discussed is FOXP3; the disease is colorectal carcinoma.