In lung cancer, the relationship between CD47 and tumor-associated macrophages is unclear, whether CD47 plays a role in affecting the prognosis of NSCLC treatment by influencing macrophage differentiation and biological behavior in the NSCLC tumor microenvironment has not been reported in the literature to date, so this was included as the focus of this study. Here, CD47 is linked to non-small cell lung carcinoma.