↑ BW (decreased in T1DM model); ↓ BW, plasma insulin levels, insulin resistance (increased in T2DM model) and ↓ s-glu, HbA1c, albuminuria, s-creat, oxidative stress, HO-1, NF-κB, mesangial expansion, ECM, fibronectin, collagen 4-α1, VEGF, endothelin-1, and TGF-β1 [93]. Here, EDN1 is linked to Insulin resistance.