MSX1 and craniosynostosis: A study of 106 individuals during autopsy in Hungary (58 males and 43 females ranging in age from 18 to 97 yo) examined DNA and cranial suture closure data (using Meindl and Lovejoy's technique) and discovered that a single nucleotide polymorphism in MSH homeobox 1 (MSX1) correlated with ectocranial suture synostosis in adults.21 Much of the research into relevant genes relates to craniosynostosis, the premature closure of the cranial sutures in neonates, which occurs in approximately 1 in 2500 births.