We confirmed the role of NCAM1 in resistance, particularly in RUNX1-RUNX1T1-rearranged AML, and identified interferon and inflammatory responses as critical to early resistance in NPM1mut cells, thereby deepening our understanding of transcriptional plasticity in BETi resistance14,16,22,47,61,62. The gene discussed is RUNX1T1; the disease is acute myeloid leukemia.