RUNX1 and acute myeloid leukemia: In addition to BRD4, we performed ChIP-Seq for central drivers and regulators of RUNX1-RUNX1T1-rearranged AML, including RUNX1, RUNX1T1(ETO), PU.1, FLI1, ERG, LMO2, p300, CDK9, the histone mark H3K27ac, and assessed chromatin accessibility dynamics via ATAC-Seq (Fig.S2A).