In both KASUMI-1 and SKNO1, p300 binding preferentially increased at sites corresponding to critical AML maintenance genes such as CDK6, CCND2-3, ST3GAL1-2,4, RUNX1, ETV6, CD34 and PVT1, which also coincided with many of the exemplar rescued genes (Fig.2A-B,E,S3C). Here, PVT1 is linked to acute myeloid leukemia.