We confirmed the role of NCAM1 in resistance, particularly in RUNX1-RUNX1T1-rearranged AML, and identified interferon and inflammatory responses as critical to early resistance in NPM1mut cells, thereby deepening our understanding of transcriptional plasticity in BETi resistance14,16,22,47,61,62. This evidence concerns the gene NCAM1 and acute myeloid leukemia.