Among the CB2R agonists, dibenzopyran derivatives are analogues of THC, the natural exogenous ligand obtained from Cannabis plant.[94] JWH‐133 4 (Figure 5) has strong potential to reduce inflammation caused by amyloid beta proteins involved in AD and plays an essential role in neuronal plasticity under conditions of neuroinflammation and neurodegeneration.[95] Its anti‐inflammatory action is due to the stimulation of the CB2R which blocks the production of proinflammatory biomarkers of the M1 state such as TNF, IL‐6, inducible nitric oxide synthase (iNOS), IL‐1β and other chemokines. Here, NOS2 is linked to Alzheimer disease.