To investigate the association between functional connectivity, baseline pathology, and longitudinal rate of tau accumulation, we utilized a sample of 110 cognitively unimpaired older adults (Table 1), n = 67 individuals from the Berkeley Aging Cohort Study (BACS), and n = 43 individuals from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Here, MAPT is linked to Alzheimer disease.