Though the spread of tau pathology in Alzheimer's disease does not always follow a single homogeneous trajectory (Vogel et al. 2021), in sporadic AD tau spread outside of medial temporal lobe predominantly occurs in inferior and lateral regions of the temporal cortex, as well as frequently in medial parietal regions such as the retrosplenial cortex and precuneus (Schöll et al. 2016; Johnson et al. 2016; Harrison et al. 2019; Sanchez et al. 2021). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.