MAP1LC3A and Alzheimer disease: Ubiquitin is a known marker of disturbed proteasomal or autophagic clearance in neurons, whereas the autophagic cargo marker p62 and autophagosomal membrane marker LC3 specifically indicate aberrant autophagy in the cell.17,19 Protein accumulation within the amyloidogenic pathway, typical for Alzheimer’s disease (AD), can be assessed by visualizing β-amyloid deposits.5