PDGFRB and Fabry disease: Key initial genes involved in FD include mutations in SLC20A2 [sodium-dependent phosphate transporter 2 (PiT-2)] on chromosome 8 and PDGFRB (Platelet Derived Growth Factor Receptor Beta) genes, which are important for upholding the integrity of the blood–brain barrier (Saleem et al., 2013; Keasey et al., 2016; Amisha and Munakomi, 2023).