In Anti Ri encephalitis, IgG binds to an intracellular RNA binding protein named NOVA-1 and NOVA-2, which are expressed in the ventral brainstem and spinal cord, causing neuronal death by CD8+ T Cells, and it is thought to be the main pathological substrate for jaw dystonia and laryngospasm seen specifically in this condition [124, 125, 38]. This evidence concerns the gene NOVA1 and Laryngospasm.