Some of the MRI changes are non-specific and could not explain the causal relationship between the brain lesion and dystonia like in NMDA (bitemporal hyperintensity and orofacial dyskinesia), LGI, IgLoN5 (cerebral atrophy and limb dystonia), GAD65 (cerebral atrophy and stiff person syndrome or lower limb dystonia), GABAA, MOG, mGluR5 associated encephalitis. The gene discussed is IGLON5; the disease is stiff-person syndrome.