However, there are some exceptions, like in anti IgLoN5 encephalitis limb dystonia responds very well to immunotherapy but craniocervical dystonia with myoclonus responds better with local symptomatic therapy [43, 44], in GAD-65 associated encephalitis young patients with high titre tend to have a better response with immunotherapy, and older patients with more atrophy have a poorer response [46, 55]. This evidence concerns the gene GAD2 and Limb dystonia.