However, in some CNS autoimmune diseases, the MRI signal changes could explain the anatomical localization of Dystonia like Anti Ri (brainstem signal changes and jaw dystonia and laryngospasm), D2R antibody (Bilateral basal ganglia signal changes and dystonia), Ma2 antibody (brainstem signal changes and jaw dystonia or upper limb dystonia). Here, PNMA2 is linked to autoimmune disease.