While we also observe increased expression and mitochondrial localization of the mitophagy mediator PARKIN, loss of PARKIN does not worsen the cardiomyopathy seen in R120G CRYAB transgenic mice, unlike the findings seen in R120G CRYAB mice with ablation of one TRAF2 allele in cardiac myocytes. Here, PRKN is linked to cardiomyopathy.