PRKN and cardiomyopathy: As we had observed that R120G CRYAB transgenic mice also exhibit increased PARKIN expression (Supplementary Figure S5), we next examined whether loss of PARKIN would also worsen the cardiomyopathy in these mice, by generating R120G CRYAB mice that were also homozygous for the Park2 null allele and therefore deficient in PARKIN (R120G-CRYAB-PARKIN KO).