Interestingly, TOsk-Gal4-driven sakura RNAi knockdown severely reduced the numbers of eggs laid (Fig 5C) and stage 14 oocytes in ovaries compared to control RNAi (yRNAi) (Fig 5D), suggesting that sakura is important for oogenesis beyond the germline cyst stage. The gene discussed is LGALS4; the disease is cyst.