Recessive variants in human POGLUT1 were previously shown to cause LGMD R21, which is associated with a severe reduction of PAX7+ satellite cells and reduced NOTCH1 signaling in patient muscles (Servian-Morilla et al., 2020; Servian-Morilla et al., 2016). The gene discussed is POGLUT1; the disease is limb-girdle muscular dystrophy.