CD133 is a pentaspan transmembraneglycoprotein, which is used as a biological marker for stem cellsand CSCs.35 Furthermore, CD133+ cells colocalizeto the hypoxic areas within pancreatic cancer, further leading toelevated HIF-1α activity.36 CD133is considered a marker of metastatic phenotype through the overexpressionof N-cadherin via the Src signaling pathway, whichplays a vital role in the EMT regulatory loop.37 CD24, a small cell surface protein anchored by glycosylphosphatidylinositol,is highly glycosylated and plays a role in cell–cell and cell–matrixinteractions. Here, HIF1A is linked to familial pancreatic carcinoma.