Impaired immunosurveillance due to diminished CD4+ counts, a hallmark of AIDS, contributes to the development of AIDS-defining malignancies such as Kaposi sarcoma, non-Hodgkin’s lymphoma (NHL), and invasive cervical carcinoma [1], while also increasing the incidence of non-AIDS-defining malignancies like Hodgkin’s disease, leukemia, multiple myeloma, and other solid organ tumors [2]. The gene discussed is CD4; the disease is non-Hodgkin lymphoma.